Cool invention! Raises the question of whether exposure to dead pathogen would still induce autoimmunity, or if it'd need to get into the cells and start churning out proteins to cause issues.
I also seriously wonder about oral vs. inhalation exposure: I could only find one case of someone getting seriously sick from drinking Legionella-contaminated tap water and they had AIDS, but I wonder if drinking it might be part of what does it in T1D.
What about developing a vaccine for Legionella that used different features of the virus? So immunity could be obtained but without the pancreas killing effect?
Dude hell yeah, this is exactly the kind of idea I was hoping to elicit.
Thinking about which protein in the bacterium hypothetically elicits the response—I just connected a dot with another study that I saw recently: https://pubmed.ncbi.nlm.nih.gov/37269833/
Seems like there's a track record of bacterial amino acid-tRNA synthases having important interactions with the immune system!
It's interesting that both Sardinians and the Nordic countries are genetically distinct from the rest of Europe. They don't have shared ancestry (unless you go really far back), but both regions were more isolated from some population waves that swept over the rest of Europe.
https://www.epa.gov/sciencematters/uv-led-showerhead-invention-reduces-risk-legionella-contamination
This work?
Last overnight at a hotel, the ice machine water filter hasn't been changed for 5 years.
Cool invention! Raises the question of whether exposure to dead pathogen would still induce autoimmunity, or if it'd need to get into the cells and start churning out proteins to cause issues.
I also seriously wonder about oral vs. inhalation exposure: I could only find one case of someone getting seriously sick from drinking Legionella-contaminated tap water and they had AIDS, but I wonder if drinking it might be part of what does it in T1D.
What about developing a vaccine for Legionella that used different features of the virus? So immunity could be obtained but without the pancreas killing effect?
Dude hell yeah, this is exactly the kind of idea I was hoping to elicit.
Thinking about which protein in the bacterium hypothetically elicits the response—I just connected a dot with another study that I saw recently: https://pubmed.ncbi.nlm.nih.gov/37269833/
Seems like there's a track record of bacterial amino acid-tRNA synthases having important interactions with the immune system!
It's interesting that both Sardinians and the Nordic countries are genetically distinct from the rest of Europe. They don't have shared ancestry (unless you go really far back), but both regions were more isolated from some population waves that swept over the rest of Europe.
Another fascinating article, thank you. I hope you find your funding and collaborators.
This is super interesting. Thank you!